Paweł Gruszczyński  Curriculum Vitae 2013,

Gdańsk, Polska

Education:

  • 2001 – 2006        MSc at Chemistry, University of Gdansk
  • 2006                    Postgraduate diploma, ETI Technical University of Gdansk
  • 2006 – 2010        PhD at Chemistry, University of Gdansk
  • 2011 – 2013        Executive MBA at GFKM / Rotterdam School of Management

Experience:

  • 2006 – 2010        LAN Administrator at Chemistry Department, Univ. Gdansk
  • 2010 – 2011        Sales Manager at BLIRT S.A.
  • 2011 – present  Business Development Manager at BLIRT S.A.

Published articles:

  1. R. J. Platt, K. J. Curtice, V. D. Twede, M. Watkins, P. Gruszczyński, G. Bulaj, M. P. Horvath, B. M. Olivera, From molecular phylogeny towards differentiating pharmacology for NMDA receptor subtypes, manuscript send to Toxicon (2013).
  2. R. J. Platt, T. S. Han, B. R. Green, M. D. Smith, J. Skalicky, P. Gruszczyński, H. S. White, B. Olivera, G. Bulaj, J. Gajewiak, Stapling mimics noncovalent interactions of γ-carboxyglutamates in conantokins, peptidic antagonists of N-methyl-D-aspartic acid receptors, J Biol Chem. 2012, doi: 10.1074/jbc.M112.350462
  3. P. Gruszczyński, D. Yoshikami, R. Kaźmierkiewicz, M-M. Zhang, B. M. Olivera, G. Bulaj, T. Cheatham IIIrd, Molecular Modeling of the Interactions Between μ-Conotoxin SmIIIA and the Pore of Voltage-Gated Sodium Channel Subtypes NaV1.2 and NaV1.4. Proceedings of 31st European Peptide Symposium, European Peptide Society, 2010.
  4. P. Gruszczyński, K. Smalara, M. Obuchowski, R. Kaźmierkiewicz. ATP and its N6-substituted analogues: parameterization, molecular dynamics simulation and conformational analysis. JMM 2010, doi: 10.1007/s00894-010-0808-3
  5. M.-M. Zhang, P. Gruszczynski, A. Walewska, G. Bulaj, B. M. Olivera,  D. Yoshikami. Co-occupancy of the Outer Vestibule of Voltage-gated Sodium Channels by μ-Conotoxin KIIIA and Saxitoxin or Tetrodotoxin -doi:10.1152/jn.00145.2010, J. Neuroscience 2010
  6. P. Gruszczyński, M. Obuchowski, R. Kaźmierkiewicz. Theoretical investigation of ATP-binding and phosphorylation related conformational changes in the structure of PrkC kinase. JCAMD 2010, 24(9):733 DOI: 10.1007/s10822-010-9370-4
  7. Twede VD, Teichert RW, Walker CS, Gruszczyński P, Kaźmierkiewicz R, Bulaj G, Olivera BM. Conantokin-Br from Conus brettinghami and selectivity determinants for the NR2D subunit of the NMDA receptor. Biochemistry. 2009 May 19;48(19):4063-73.
  8. Han TS, Zhang MM, Walewska A, Gruszczynski P, Robertson CR, Cheatham TE 3rd, Yoshikami D, Olivera BM, Bulaj G. Structurally minimized mu-conotoxin analogues as sodium channel blockers: implications for designing conopeptide-based therapeutics. ChemMedChem. 2009 Mar;4(3):406-14.
  9. Gruszczyński P, Kaźmierkiewicz R, Obuchowski M, Lammek B. Theoretical Modeling of PrkCc, Serine-Threonine Protein Kinase Intracellular Domain, Complexed with ATP Derivatives. QSAR and Combinatorial Science 2007 Sep 17; 27(4):437-444

Posters:

  1. P. Gruszczyński, R. Kaźmierkiewicz, M. Obuchowski. Phospohrylation and ATP-binding induced conformational changes in PrkC, a Ser/Thr kinase from B.subtilis. 4th European Spores Conference, 27-29.05.2010, Cortona, Italy
  2. P. Gruszczyński, M. Obuchowski, R. Kaźmierkiewicz, Theoretical studies on conformational changes imposed by phosphorylation and ATP binding in serine/threonine kinase from Bacillus subtilis, PrkC. Inhibitors of Protein Kinases, Warszawa, 27.06-01.07.2009
  3. P. Gruszczynski, K. Smalara, M. Obuchowski, R. Kazmierkiewicz, Modeling the phosphorylated and unphosphorylated serine-threonine kinase, PrkC with and without its natural ligand, ATP, 25’th All-Polish School of Chemistry in Ciazen, 16-19.09.2007
  4. K. Smalara, P. Gruszczynski, R. Kazmierkiewicz, Predicting ATP pocket in model of the PrkC, serine-threonine kinase, 25’th All-Polish School of Chemistry in Ciazen, 16-19.09.2007
  5. P. Gruszczynski, R. Kazmierkiewicz, M. Obuchowski, Theoretical research of the activity mechanisms of the phosphorylated and unphosphorylated PrkC kinase, 25’th All-Polish School of Chemistry in Ciazen 10-14.11.2006
  6. P. Gruszczynski, K.Smalara, R. Kazmierkiewicz, Methods of theoretical modeling of the PrkC kinase intracellular domain, complexed with ATP and its derivatives, All-Polish Symphosium of the Chemistry Students in Jeziory, 09.27-29.2006
  7. P. Gruszczynski, R. Kazmierkiewicz, M. Obuchowski, Theoretical modeling of the cathalytic subunit of the PrkC protein kinase with the ATP and its derivatives .41’st Annual Meeting of the Polish Biochemical Society in Białystok, 12–15.09.2006.
  8. P. Gruszczynski, K. Smalara, R. Kazmierkiewicz, Conformational analysis of the ATP derivatives in the presence of the Mg2+ ions using molecular dynamics methods, 24’th All-Polish School of Chemistry in Kościelisko, 3-7.05.2006
  9. R. Kazmierkiewicz, P. Gruszczynski, M. Obuchowski, Theoretical modeling of the complex of protein kinase (PrkC) with its ligand – a modified ATP 18’th Polish Peptide Symphosium in Wroclaw, 4-8.09.2005
  10. P. Gruszczynski, P. Czaja, ATP – molecular battery, 22’nd All-Polish School of Chemistry in Wisla, 29.04-05.04.2005

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